The Muse in the Middle

Stem cell replacement therapy— A gift from the gods or the end of our ethics?

When it comes to stem cell news, there seems to be no middle ground. It’s reported that either stem cell replacement therapy is a gift from the gods or it’s the end of our ethics as we know them. Very few news articles have taken the time to step away from the hype and answer some very basic questions. So, if you will, please allow me.

What’s in a Name?

Regenerative medicine focuses on regaining lost or impaired body function. Adult stem cells can replace cells that have died or just stopped working effectively. Athletes have found that they help to heal or prevent injuries. Research has also shown stem cells can help fight certain diseases and serve as an anti-aging treatment. And, of course, stem cell transplants have been used since 1957 to restore the immune system after chemotherapy for cancer and these treatments continue to be improved and used today. It’s all good stuff.

Part of the controversy surrounding stem cell replacement, pounced on by the media, is the idea that stem cells must be retrieved from human embryos or specifically the umbilical cord, which has raised ethical concerns. But the reality is that all approved therapies in the United States do NOT include cells harvested from fetal tissue and are either performed using adult stem cells or those collected from donated (and otherwise typically discarded) umbilical cords of successful healthy births. And yes, more investigation into adult stem cell use needs to be done, but the idea that medical researchers are looking to “frankenstein” the human body or scavenge for stem cells is hyperbole, to say the least. One impetus for stem cell treatments is the success observed using what one person already has an abundance of to give someone else a new lease on life, much like a transplant but much less invasive and more accessible. It’s a procedure that dates back to 1948 and was expanded in 1968 when the first adult bone marrow cells were used in clinical therapies for blood disease.

There are different kinds of adult stem cells, categorized differently depending upon their capability or potency, their use and their derivation (as well as by the branch of science or medicine that is doing the categorizing): three main types found in the blood and bone marrow called hematopoietic stem cells, mesenchymal stem cells, endothelial stem cells, but there are other types found throughout the body, and each of these has a predilection to replace a particular type of cell. One of the most versatile types of cells is called a Muse cell – a type of cell that resembles a stem cell that increase in number under conditions of considerable stress, and exist in the blood, bone marrow, and connective tissue of various organs. So, when an organ isn’t working properly, stem cells and Muse cells collected from a donor can be administered to a patient through an IV infusion, intramuscular or intraarticular injection to regenerate tissue and restore functionality. Some might call them a doctor’s muse for healing. Too much? 

Why is the FDA Being Cautious?

The FDA is in the middle of the debate over these new therapies. They are tasked with regulating regenerative medicine products to ensure that they are safe for patients. Just like any other type of drug or medical procedure, the FDA must be cautious because they have to protect the best interest of the patient. They demand strict testing and evidence to show that these treatments aren’t harmful. But sometimes oversight can be a slow process, and, while use of stem cells and even Muse cells have been proven safe and often efficacious in many other countries, the process of proving the efficacy and safety here in the United States has not been completed. Meanwhile, patients should be wary of unqualified doctors trying to take advantage by marketing therapies that have not yet been approved or for which they have not undergone proper training.

It’s important to be your own medical advocate and do your homework. Know what regenerative therapies have been approved and what products or services are undergoing legal clinical trials. Work in consultation with your physician, and don’t take any unnecessary risks. Seek advice as if you were undergoing any other medical procedure.

Options Available Now

So, what’s available now for those interested in stem cell therapies? First, you can ask your doctor if there is a trial in your area or a reputable clinic in another country. Look for studies that mention “IRB Approval” or are part of an “IND Study” since these are those that have FDA oversight and approval to be undertaken. Take advantage of websites that provide an overview of trials and clinics throughout the world.  One of the best sites is run by The International Society for Stem Cell Research. It provides links to a wide range of other resources too. Depending on your ailment, you could also try to work on the reverse by matching your issue with a potential stem cell treatment. 

Educate yourself about whether a given clinic or treatment has been the subject of lawsuits, controversy, or negative (and well researched) publicity. Some stem cell purveyors exaggerate claims, take shortcuts with their techniques, and engage in other practices that are morally dubious. Look for clinics run by individuals with strong science and medical credentials.  Ask your doctor about the validity of their methods and specific stem cell extraction and infusion approaches.  Beware of any clinic that is selling stem cells like a late-night TV pitchman hawking slicers-and-dicers.  

Then, set a budget and determine how much, if any, insurance is willing to cover. Currently, most insurance plans will only cover stem cells collected through bone marrow transplants. Be mindful that different methods have different associated costs. In many cases, liposuction is the most cost-effective option, and those stem cells can be expanded, offering more bang for the buck.

Finally, keep track of emerging treatment developments.  Stem cells represent a rapidly evolving field, not just scientifically but from a regulatory perspective.  Invariably, new and more effective treatments will emerge for a wide range of conditions. At the same time, stem cells will gain greater acceptance overall—while the media continues to play catch up. 

Dr Rand McClain Reverse Aging, Increase Testosterone Naturally, HRT, TRT, Sleep, Steroid Cycles, PCT

A podcast beyond bodybuilding and fitness. Across the borders. About mental toughness, dedication, business (strategies), society, ethics, moral, philosophy, virtue/s, self consciousness and awareness.

Avenues to slow down aging and what makes us age 11:03 importance of sleep, diagnostic wearables, aura ring 16:14 how to improve sleep, Rand’s view on medications 21:05 Doc’s stance on Melatonin 23:54 CBD for sleep 24:14 What makes Studies relevant and applicable 29:49 Hormone Replacement Therapy, short cuts and weight loss 32:44 Hematocrit, optimal diet for the individual and Blood Type diets 37:44 Mudho DNA-Test, health screening, problem with diagnostics 40:49 important blood markers for health checks 44:24 prescribable peptides for neuroproteciton, cognition and HGH, life quality 46:42 use it or lose it, the basics to a healthy life 48:04 biggest mistakes using anabolics! And how to approach being “off” 50:54 Golden era cycles and PCT 51:48 PCT or TRT? Any benefits to going off completely? 55:24 DEA trying to change regulations on HRT And substance control controversy

Dr. Rand McClain: Living Longer and Living Better The Optimal Life with Nate Haber

Dr. Rand McClain is a longevity expert who believes humans may one day be able to live to 150 and beyond.  He is the founder of Regenerative & Sports Medicine, a clinic specializing in hormone replacement, stem cell and other therapies to enhance patient lives.  His book, “Cheating Death: The New Science of Living Longer and Better,” provides strategies for improved healthspan that can lead to a longer lifespan.

Learn more at

Connect with Dr. Rand on Instagram @Dr.RandMcClain

If you enjoyed this episode, you might also like: 

Ep. 170 – Dr. Jim Hrncir :: The Beautiful Science Behind Anti-Aging 

Ep. 20 – Dr. M Kara, anti-aging expert specializing in hormone replacement therapy

Living Your Best Life with Your Best Health – special guest Dr. Rand McClain

Welcome to the Middle Age(ish) Podcast, hosted by Ashley Bedosky, Lisa Kelly, Dr. Pam Wright, and Trisha Kennedy Roman. In this episode, we speak with Dr. Rand McClain, author of the book Cheating Death – The New Science of Living Longer and Better. Dr. McClain is a world leader in treatments for longevity and anti-aging.

He is a wealth of information on regenerative medicine, from hormone replacement therapy in males and females, stem cells, ketamine therapy, weight loss, and so many other modalities that can help us optimize our health.

“The beauty of the medicine we have available to us now is we have a lot of options.” – Dr. Rand McClain – Author of Cheating DeathWe could have talked to Dr. McClain for hours more, as the information he discussed was truly fascinating! He has a tremendous passion for helping others. We were all ready to stock our medicine cabinets with the three supplements he most recommended as well as start ensuring we get proper rest!

Lisa Kelly to Dr. McClain, “You just sound so passionate about what you do, which is just so heartwarming.” We hope you find this discussion as interesting as we did. This was one more talk to help us all on our journey towards living life to the fullest in every season of life, but especially in this middle age(ish) season of life we are in right now!

We were excited to find out that Dr. Rand also does telemedicine and you can book a VIP call with him by clicking HERE.

You can find out more about the book Cheating Death – The New Science of Living Longer and Better by clicking HERE. You can also find Dr. Rand McClain on instagram @dr.randmcclain

If you’re a middle age woman who loves connecting with other women and chatting about relatable issues, pour up a glass of wine or a cup of tea and tune in! In future shows, we’ll be bringing in some incredible guests and specialists to talk about these issues further and bring some positivity into being Middle Age(ish). So, subscribe and follow along! Middle Age(ish): A time of transition from dreaming of who we will grow up to be and looking at the legacy we will leave behind.

Cheating Death with Dr. Rand McClain: Rational Wellness Podcast 299

Dr. Rand McClain discusses How to Cheat Death with Dr. Ben Weitz.

Podcast Highlights

3:15 Dr. McClain feels that there is a lot of science behind the DNA methylation tests to gauge the rate of biological aging and at this point is the best way to gauge our rate of aging. He recalls doing a test like this prior to the recently commercialized TruAge version that cost as much as $10,000. Next best to DNA methylation is testing for telomere length. Dr. McClain has developed an app, the death clock, that is a biological clock evaluation based on biomarkers.

14:35 Dr. McClain had prostate cancer six years ago and was able to cure it with a natural approach by taking specific polyphenols, including green tea extract (EGCG) and cayenne pepper. He also used Metformin to lower his sugar levels. Dr. McClain pointed out that while this approach worked for him, he is not recommending it for others with cancer.

20:36 Rather than take NAD+ precursors like NR or NMN, as others in the longevity research space recommend, Dr. McClain feels that the best NAD+ stimulator is exercise. He does recommend sustained release Beta-alanine, which improves your exercise capacity, as an anti-aging supplement. Another supplement that Dr. McClain recommends is a form of Cat’s Claw herb, AC-11, in order to help repair our DNA. He also personally takes Rapamycin once per week, which is an mTOR inhibitor for longevity purposes. While he takes Rapamycin once per week, he will use a peptide that is a growth hormone secretagogue to try and balance out the GH suppressing effects of Rapamycin.

Episode #142: Stem Cells & Other Cutting Edge Modalities

My guest this week is Dr. Rand McClain of Regenerative and Sports Medicine.

In this episode, Dr. Rand McClain and I discuss stem cells, epigenetics, blood sugar and regenerative medicine as a whole. Dr. Rand shares some patient stories of reversal of arthritis and even MS symptoms in people. We discuss the cutting edge modalities you may have been wondering about or even heard multiple contradictory viewpoints on and he sets the record straight.

Though nutrition and wellness have been ingrained in Dr. Rand McClain since childhood, his journey to becoming a leader in alternative and progressive medical treatments has been anything but orthodox. From being the youngest senior account manager in Deloitte’s history, to his stint as a professional boxer in Argentina, to being accepted to medical school at age 37 after being repeatedly told it was impossible, Dr. Rand has never been a fan of the “status quo”.

Dr. Rand’s patients (many of which are A-List celebrities and world-class athletes) come to his practice, Regenerative and Sports Medicine, in search of the innovative treatments he specializes in. From bioidentical hormone replacement therapy (BHRT), hyperbaric oxygen therapy to cryotherapy, Dr. Rand has dedicated the past 35 years to redefining what it means to be in optimal health.

Cheating Death – The new science of living longer and better With Dr. Rand McClain and Guest Host Valerie Pope

Though nutrition and wellness have been ingrained in Dr. Rand McClain since childhood, his journey to becoming a leader in alternative and progressive medical treatments has been anything but orthodox. From being the youngest senior account manager in Deloitte’s history, to his stint as a professional boxer in Argentina, to being accepted to medical school at age 37 after being repeatedly told it was impossible, Dr. Rand has never been a fan of the “status quo”.

Dr. Rand’s patients (many of which are A-List celebrities and world-class athletes) come to his practice, Regenerative and Sports Medicine, in search of the innovative treatments he specializes in.

In his book, Cheating Death: The New Science of Living Longer and Better, due to be released in March 2023 (available for pre-order now at, Dr. Rand takes a fresh approach to genetics, natural aging, and proactive medical treatments by sharing the best drugs and supplements, treatment methods, and devices—approaches that are backed by extensive research, as well as outlines how readers can get access to these therapies to jumpstart their body’s regenerative processes. Bolstered with research and recovery stories from real people, Cheating Death gives readers the tools to live healthier, longer lives.

869 – Dr. Rand McClain: Peptides and Hormones

On this episode we have one of the leading experts on hormones and peptides, Dr. Rand McClain!

Peptides are emerging into the health and fitness space as one of the most beneficial and impactful supplements on the market, because they have been shown to produce unbelievable results with minimal (if any) side effects at all. This is primarily because our body already makes these amino acids. But because they are so versatile, scientists can create any combination of them to formulate peptides for whatever desired effect they want. Again, making them extremely beneficial AND in demand.

Which is why we brought Dr. Rand McClain on the show! To give us a “Peptides 101” master class, while helping us also understand how they are connected and interrelated to hormones in the body.

So join us and learn what peptides are, how they work in the body, how they work, the connection to hormones they have, and the results they can produce for everything from body composition to health to longevity.

And make sure you order Dr. Rand McClains new book, “Cheating Death: The New Science Of Living Longer and Better”. HERE

You can also follow Dr. Rand McClain on instagram @dr.randmcclain

If you love this podcast, please do us a favor and share this episode with anyone you think would like it or benefit from it. Thank you!

Cheating Death: The Science on How to Live Long and Prosper with Dr. Rand McClain

Host Johnny Punish welcomes Dr. Rand McClain, one of the foremost leaders in longevity and regenerative medicine.

He is a medical advisory board member at The National Veteran Foundation. Together they talk about living longer and happier and discuss the release of his new book;

“Cheating Death: The New Science of Living Longer and Better” which is available on In addition, they discuss the use of Ketamine as a therapy for Post Traumatic Stress Disorder (PTSD).

In fact, with outstanding results, Dr. Rand has been working with Veterans diagnosed with PTSD at his clinics in Los Angeles and Houston.

It is not well publicized but he offers them complimentary Ketamine therapy when appropriate for their PTSD.

He has had great success in the utilization of Ketamine therapy. What is Ketamine Therapy?In addition to treating severe symptoms of depression, ketamine is being used to successfully treat PTSD (post-traumatic stress disorder) and chronic anxiety disorders. Besides its relatively newfound efficacy in treating formerly treatment-resistant aforementioned disorders safely and cheaply, much of the excitement surrounding ketamine use include the ability to do so rapidly – usually within the first course of treatment.